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Deciding on the best approach and delivery system is key

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Finally, on-treatment moderate or severe incident GI adverse events were associated with a higher hazard of discontinuation for patients with type 2 diabetes (HR, 1.38 [95% CI, 1.31-1.45]) and for patients without type 2 diabetes (HR, 1.19 [95% CI, 1.12-1.27])

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The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagalbrainstem-hypothalamic pathway

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Azar suggested that the US could look at what other countries are doing, but coverage of GLP-1 drugs elsewhere is limited and evolving

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