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This response was blocked by a NOS inhibitor with high selectivity for the neuronal enzyme and by a guanylyl cyclase inhibitor

By integrating regular physical activity with polyphenol-rich diets, individuals can target multiple mechanistic pathways, including neurotransmitter modulation, neurotrophic support, inflammation control, and mitochondrial protection

These processes include antianxiety, diuresis, and neurotransmission (161)

Similarly, decreased ceramide production could also lead to downregulation of its transporter, CERT1 (Fig

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