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Despite these limitations, Arabidopsis thaliana can serve as an integrative platform for dissecting conserved cellular mechanisms-particularly those involving Ca 2+ homeostasis, redox regulation, and organelle stress

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[21] Furthermore, an animal study in ewes demonstrated that a B 12 , folate and methionine restricted diet around conception, resulted in offspring with higher adiposity, blood pressure and insulin resistance which could be accounted for by altered DNA methylation patterns

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