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Behavioral studies in AD 3xTg-AD transgenic mice have reported memory impairment and enhanced amyloidogenic processing following chronic metformin administration, raising concerns about its effects in non-DM2 populations 92

The study also found that it improved several heart and metabolic health factors, including cardiovascular benefits, providing additional advantages for individuals at risk of heart disease

For patients experiencing weight regain or plateau, this additional weight reduction may help achieve or maintain clinically meaningful weight loss thresholds associated with improved cardiometabolic outcomes

We have found that for these patients there is a trend towards increased weight gain after therapy cessation despite the longer duration of therapy