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Microglia activation and neuroinflammation in ASD Microglial activation was assessed via Iba1 immunofluorescence staining in the hippocampal CA1 region and prefrontal cortex of VPA-exposed SD rats to evaluate neuroinflammatory pathology

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27 Consistent with the lack of mitochondrial involvement, erastin did not cause ATP depletion, and morphologically, mitochondria appeared smaller and denser, but not swollen or ruptured as seen in classical necrotic cell death