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In an accompanying manuscript, we describe preclinical studies in obese mice and non-human primates showing that GDF8 and ActA mAbs in the setting of GLP1-induced weight loss can maintain and even increase muscle mass, with associated metabolic benefit including reduced adiposity, thus providing a potentially better approach to weight loss and maintenance 23 , consistent with the findings observed when treating obese mice with bimagrumab and a GLP1-receptor agonist 24

Other key compounds such as alprogen and chromium have also been shown to lower blood glucose levels, restore pancreatic -cell function, and enhance insulin activity [44]

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Retatrutide and intermittent fasting work through complementary mechanisms that can amplify fat loss results when combined strategically

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