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275 , G984G992 (1998)
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It is becoming increasingly clear that, by looking at single cells types separately or isolated islets, deprived of the natural microcirculation, one misses important paracrine effects that each hormone and cell type exert on its surrounding cells, because all substances reach the peripheral cells by uncontrolled diffusion
Many considered this an overblown response to a small outbreak, aimed at acquiring more research funding, especially when years went by without an H5N1 pandemic, despite the widespread, continued circulation of HPAI H5N1 in poultry with regular spillover to humans, resulting in more than 850 human cases and over 450 deaths to date 3
