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To put that into perspective: Semaglutide (Wegovy) reported around 14.9% weight loss in STEP-1 Tirzepatide (Zepbound) reported around 22.5% in SURMOUNT-1 Retatrutide reached 28.7% in TRIUMPH-4 More Than Weight Loss One of the most important aspects of TRIUMPH-4 was that it demonstrated improvements beyond body composition alone

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For instance, in Cogans syndrome the immunoglobulin G (IgG) immunoglobulins have an affinity for a supporting protein in the sensory epithelia of the inner ear Density-Enhanced Protein tyrosine phosphatase-1 (DEP-1/CD148) as well as connexin 26 that results in sensorineural hearing loss in mice [58]