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This is the first genome-wide association study in hepatology that established ABCG8 as the most important genetic risk factor in humans

The thick ascending limb of the loop of Henle contains medullary (MTAL) and cortical (CTAL) epithelial cells

While both of these approved mAbs bind to the unstructured N-terminus of their respective receptors, likely in a manner similar to traditional antibody-peptide complexes, the recognition of conformational epitopes composed of the highly dynamic extracellular loops (ECLs) is likely required for the successful development of antibody antagonists or agonists against other GPCRs

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