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Continued research led to the first GLP-1 drugs approved for weight loss in people with obesity or overweight: liraglutide or Saxenda in 2014, semaglutide as Wagovy in 2021 and tirzepatide as Zepbound in 2023

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SGLT1 inhibition can delay and reduce glucose absorption in the proximal gut, thereby improving postprandial glucose control, and SGLT2 inhibition can reduce renal glucose reabsorption [22]