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Key dietary changes that may contribute to loose stools include: Increased fibre intake: Switching to vegetables, legumes, wholegrains, and fruit is nutritionally beneficial, but a sudden increase in dietary fibre particularly insoluble fibre can cause bloating, wind, and loose stools until the gut adapts

CCR8 also has a unique PMS activation motif instead of the canonical P 5.50 I 3.40 F 6.44 sequence, and is the only chemokine receptor that has a Ser instead of an aromatic residue at position 6.44 (Supplementary Fig

Reddy 2011a

Unlike normal blood vessels, tumor vasculature displays multiple functional and structural abnormalities characterized by unusual leakiness, high tortuosity, and poor coverage by pericytes (Dudley, 2012

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