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MOTS-c inhibited the folate cycle at the level of 5Me-THF, resulting in an accumulation of AICAR [5-aminoimidazole-4-carboxamide ribonucleotide), a well-defined AMPK activator [58]

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Side Effects While Tirzepatide offers benefits for diabetes and weight management, it may cause side effects, including nausea, vomiting, temporary diarrhea, reduced appetite, and increased risk of low blood sugar (hypoglycemia), especially when combined with other diabetes medications