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In the SURMOUNT-1 trial involving adults with obesity or overweight without diabetes, participants achieved mean weight reductions of approximately 15% to 21% over 72 weeks, depending on dose

Hepatocyte injury and dysfunction interrupts active protein biosynthesis in the liver and lack of their utilization, leading to increased levels of free amino acids in both the liver and blood

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Patients typically take methotrexate once weekly (orally or by subcutaneous injection), alongside folic acid supplementation to minimise side effects