anhedonia semaglutide TheCut just released an article on one of the long-term side effects of GLP-1s Understanding Desire in the Age

There was a progressive decrease of the proportion of patients at target for each 0.5% increase in baseline HbA1c, ranging from 57.8% for HbA1c 7.5% to 20.8% for HbA1c 10% (p for trend 9.0% with no further decrease, whereas for non-insulin drugs the relationship was continuous without any evidence of plateau 5

"We wouldn't have undertaken this head-to-head phase three randomized control trial unless we had a lot of confidence that orforglipron would fare well in comparison to oral semaglutide," Skovronsky said

So, be smart and consult your doc

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The certainty of evidence, assessed using GRADE methodology, ranged from high for colorectal cancer to moderate for liver cancer to low for pancreatic cancer, reflecting variations in trial consistency and event rates ( Since most studies focused on liraglutide and semaglutide, the outcomes are most relevant to these drugs, even though the pooled analysis considered all data from the GLP-1 RA class