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To protect patient safety, organizations must use insulated packaging that keeps medications within the labeled temperature range, ensure chain-of-custody, and manage risks like delays, temperature fluctuations, or improper handling in transit

Fat cells release inflammatory mediators known as adipokines , including: Leptin Adiponectin Interleukin-6 Tumor necrosis factor-alpha These mediators contribute to: Cartilage degradation Synovial inflammation Osteophyte formation Because of these mechanisms, obesity is considered one of the most important modifiable risk factors for knee osteoarthritis