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The most frequently reported side effects include gastrointestinal symptoms such as nausea, diarrhoea, vomiting, constipation, and abdominal pain , which affect a significant proportion of patients, particularly during dose escalation

10.1016/j.pharmthera.2005.01.001 104 KumagaiT.SuzukiH.SasakiT.SakaguchiS.MiyairiS.YamazoeY.et al (2012)

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