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A total of 30 male BALB/c nude mice were randomly divided into four groups: a CT26 + 0.9%NaCl group (8 mice bearing CT26 tumors, treated with vehicle, as a control model of cancer cachexia), a 0.9%NaCl group (6 mice without tumors, treated with the vehicle, as normal controls), a CT26 + LC1 group (8 mice with CT26 tumors, treated with1 mg/kg bodyweight L-carnitine) and a CT26 + LC10 group (8 mice with CT26 tumors treated with10 mg/kg bodyweight L-carnitine)

These studies suggest the mitochondria [2] offer active regulation of metabolic homeostasis via this peptide encoded in their genome

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DOI: 10.1159/000341454 [Google Scholar] Xu WW, Guan MP, Zheng ZJ, Gao F, Zeng YM, Qin Y, et al