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Comment on Brain IRS2 signaling coordinates life span and nutrient homeostasis

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doi: 10.1186/s13395-025-00375-5

Remarkably, carnosine, a naturally occurring dipeptide composed of -alanine and L-histidine, was identified as a consistently downregulated metabolite in both models ( Mechanistically, our in vitro data revealed that carnosine not only suppressed LPS-induced cytokine production in BMDMs but also inhibited their polarization toward the M1-like pro-inflammatory phenotype, which is known to exacerbate lung tissue damage ( The strength of our findings lies in the use of two distinct injury models: LPS, which induces Toll-like receptor 4 (TLR4)-mediated acute inflammation mimicking bacterial pneumonia, and papain, which simulates protease-mediated epithelial injury and allergic-type inflammation

Inhibition of lipid oxidation increases glucose metabolism and enhances 2-deoxy-2-[(18)F]fluoro-d-glucose uptake in prostate cancer mouse xenografts