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This efficiency reflects the designers understanding that the triple receptor profile provides robust efficacy even at the earlier dose levels, allowing for a more streamlined escalation

These ligand-mediated approaches expand the range of tumors accessible to phytochemical-based nanotherapy, including those protected by physiological barriers or with low passive accumulation

The MRSD can be further refined based on the anticipated therapeutic window : the dosage range sitting between the minimum effective concentration (MEC) and the minimum toxic concentration (MTC)

For the intervention, the rats in the PDA (3.6 mg/kg) and PDA@Pt (5 mg/kg) nanomedicine groups received intra-articular injections of the respective nanomedicines into the right ankle joint

Therefore, -LA is an essential biomarker for both prevention and treatment of migraine (147)