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In saliva, but not in serum, various polyphenols, and the microbial metabolite 5-(3,4-dihydroxyphenyl)--valerolactone were exclusively present as unconjugated molecules ( 6.3 Site-specific metabolism: blood cells The observation of a facilitated uptake of 5-(3,4-dihydroxyphenyl)--valerolactone into blood cells and its determination in cell samples of osteoarthritis patients after intake of Pycnogenol (see section 5.2 Distribution into blood cells) prompted systematic advances to elucidate the detailed metabolism of 5-(3,4-dihydroxyphenyl)--valerolactone in human blood cells ( ( 7 Elimination The major excretion routes of dietary polyphenols and their metabolites include renal and biliary elimination of compounds circulating in blood

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51 Antiviral efficiency of such treatment has been demonstrated by a study of Flora with co-workers [4] 52 showed that six-month preventive administration of N-acetylcysteine (NAC, precursor of glutathione), 53 significantly reduced the incidence of clinically apparent influenza and influenza-like episodes, especially in 54 elderly high-risk individuals

Clinical and molecular landscape of post-traumatic osteoarthritis

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