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Despite its advantages, efficacy is dose-dependent, and higher doses are often limited by the risk of adverse effects, particularly hepatotoxicity (Yelamos & Puig 2015)

Tariq R, Pardi DS, Bartlett MG, Khanna S

in the Journal of Endocrinology and Metabolism reported AOD 9604 to be well-tolerated across tested doses, with no observed alterations in IGF-1 levels, blood glucose, or insulin sensitivity

Rhodiola has been demonstrated to enhance BDNF levels and activate the ERK/CREB signaling pathway (12), thereby facilitating neuronal survival and promoting neurogenesis within the hippocampus