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The positive health impacts seen in people with type 2 diabetes who take metformin, coupled with fascinating findings from animal studies, have sparked an intriguing question: could metformin be the key to unlocking longer, healthier lives?

On mechanism, the peptides and the small molecules end up at the same destination (Gs activation, cAMP elevation, the canonical incretin pharmacology) but they get there via different binding modes and with different signalling profiles

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STABLE GASTRIC PENTADECAPEPTIDE BPC 157 HEALS CYSTEAMINE-COLITIS AND COLON-COLON-ANASTOMOSIS AND COUNTERACTS CUPRIZONE BRAIN INJURIES AND MOTOR DISABILITY 2Department of Pathology, Medical Faculty, University of Zagreb, Zagreb, Croatia INTRODUCTION Several important findings recently appear in inflammatory bowel disease (IBD) and ulcerative colitis (1, 2) in particular, alterations of the brain-gut interactions ("brain-gut axis") (3) while stable gastric pentadecapeptide BPC 157 particular effects on nitric oxide (NO)-system (4), nonsteroidal anti-inflammatory drugs (NSAIDs)-toxicity, peripheral and central (5), gastrointestinal tract (6, 7) and wound-healing, and blood vessels (8), were recently reviewed