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The enzymes DNA methyltransferases catalyze the transfer of methyl groups, derived from SAM, to the CpG islands in the promoter region of a gene, preventing the interaction of this region with the transcriptional machinery and consequently blocking gene expression (Triantaphyllopoulos et al., 2016) ( Figure 1 )

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Protection by protein binding of toxic adducts or transition metals (copper or iron) to albumin, transferrin, ferritin, ceruloplasmin or metallothionein, provides another rapid venue for detoxication (liver and systemic circulation)

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Probiotics may help alleviate these symptoms by restoring gut microbiota balance and enhancing digestive function

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