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NAD+ is a coenzyme essential for various biological processes, including DNA repair, mitochondrial function, and reducing oxidative stress

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Introduction Brain-derived neurotrophic factor (BDNF) Receptors of BDNF and signalling pathways BDNF has neuroprotective effect in experimental stroke models Applications and challenges Conclusion Hypoxia-ischemia (H/I) brain injury results in various degrees of damage to the body, and the immature brain is particularly fragile to oxygen deprivation, termed hypoxia-ischemia brain damage (HIBD), which can be caused by extreme prematurity or perinatal asphyxia