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Critical revision of the manuscript for important intellectual content: FF, BM, and SYS

Retatrutides effect on the GIP receptor (known for its role in natural insulin secretion) contributes to improved glucose homeostasis

This last appears to be influenced by naltrexone centrally and/or by the increase of gonadal steroid plasma levels as soon as the menstrual cyclicity is restored, thus confirming that opioidergic tone and/or steroid milieu is deeply involved in the modulation of the many central nervous system functions/activities such as the hypothalamic centers ruling food intake