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These pathways operate both independently and in an interconnected manner, jointly determining the intensity of the host inflammatory response and balancing the immune response by regulating key transcription factors such as NF-B, MAPK, and IRF3 [286]

Angiogenic signaling is a recurring theme in this area because vascular development plays an essential role in delivering oxygen, nutrients, and osteogenic precursor cells to healing bone tissue

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Therefore, decreases of dopamine in PD patients may lead to glucose metabolism disorders (Fig