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[26] showed that liraglutide-dependent weight loss relies on its binding to GLP-1Rs located mainly in POMC/CART (cocaine- and amphetamine-regulated transcript) anorexigenic neurons in the ARC, but an indirect inhibitory effect of agouti-related peptide (AgRP) orexigenic neurons via -aminobutyric acid (GABA)-ergic signaling was also observed

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Smart use of NPPA, NLEM updates, NP-NCD inclusion, and selective insurance coverage can turn a global blockbuster into a large-scale public-health tool.[6] 9