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L-Carnitine is responsible for the transport of long-chain fatty acids into the mitochondria of cells

This combination would theoretically provide a relatively fast onset of CV benefit (1-3 months) by the SGLT-2 inhibitor with potentially further augmented reductions in MACE exhibited 12 to 18 months later as a result of the GLP-1 RA

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Many plans additionally require a trial of a preferred alternative agent and documented follow-up with demonstrated response for continued authorization