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N Engl J Med 369:13271335 Shirakawa J, Fujii K, Ohnuma K et al (2011) Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice

SGLT2 inhibitors, in contrast, expand the brains energetic flexibility by increasing access to ketone substrates

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Estrogen-sensitive neurons are involved, but estrogen isnt the only cause of hot flashes.[ref] Neurokinin B plays an important role: In the hypothalamus, neurokinin B (NKB) signals to its receptor during hot flashes

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