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GSDMD, the pyroptosis executioner protein, forms plasma membrane pores via its N-terminal domain, causing cell death and releasing pro-inflammatory factors (IL-1, IL-18, HMGB1) that activate neighboring glial cells and recruit peripheral immune cells, amplifying neuroinflammatory feedback loops [49]

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Masculinized mutants lack male somatic tissues, but they produce a large number of sperm 26 , substantially greater than the ~300 sperm typically produced by hermaphrodites