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The injection of fentanyl to vehicle (saline)-pretreated rats elicited a sustained reduction in fr that was associated with pronounced long-lasting increases in Ti and EIP (at least 60 min) and pronounced but shorter-lived increases in Te and EEP (about 15 min in duration)

For step-by-step instructions, see the Melanotan 2 Reconstitution Guide

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These effects are similar to those caused by metformin, a well-established anti-diabetic medicine