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Still, our data raise the possibility of several additional nodes of regulation of the CIA in response to cysteine limitation that are worthy of further exploration, including inhibition of cytosolic cluster synthesis due to cysteine insufficiency, restriction of mitochondrial cluster export, or differential cluster integration into recipient proteins through the regulation of the chaperone-based trafficking system 79

A systematic review of nine studies (165 patients) evaluating various addictions (cocaine, cannabis, nicotine, methamphetamine, pathologic gambling), confirmed the potential of NAC for the treatment of addiction, especially to cocaine and cannabis [135]

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