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Clearing one bottleneck does nothing for the other, which is the rationale for stacking

Springer Jahoor F, Taffet GE, Sekhar RV

gastroenterology WJG 20 (25), 80828091

Therefore, downregulation of SIRT1 during aging promotes p53 expression and may increase the vulnerability of neuronal cell deaths following ischemic stroke

The animal experiments in this study were conducted in animal experimental facilities certified by the International Laboratory Animal Evaluation and Certification Management Committee and approved by the Institutional Animal Care and Use Committee at Tianjin Tiancheng New Drug Evaluation Co., Ltd