mounjaro a semaglutide Ozempic® (semaglutide) and Mounjaro™ (tirzepatide), major breakthrough for the treatment of obesity Mounjaro Weight Loss Injections in

1 Similarly, liraglutide 3.0 mg daily resulted in a mean weight loss of 8.4% in the SCALE trial

In those cases, switching can make sense, but it should always be done thoughtfully, with medical guidance, and with attention to dosing

GBA1 mutations decrease -glucocerebrosidase (GCase) activity, leading to sphingolipid metabolite accumulation (e.g., glucosylsphingosine), lysosomal membrane destabilization, and impaired transcription factor EB (TFEB) nuclear translocation, downregulating lysosomal biogenesis [156]

Table 1 Summary of anticancer effects and underlying mechanisms of SFN

Regarding the suggestion we adopt a flexible approach in its review of FMV documentation, because we did not propose a policy for CMS's review of reasonable assumptions, this comment is out of scope