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concurrently, BNIP3 recruits Parkin to mitochondria to initiate autophagic flux, whereas NIXas a ubiquitination substrate of Parkinundergoes conformational remodeling post-modification to specifically engage adaptor protein NBR1, ultimately enabling targeted autophagic degradation of compromised mitochondria (Wang et al., 2023)

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2 Alterations of the gut microbiota in depression Gut microbiota is a reservoir of trillions of bacteria, archaea, viruses, parasites, and fungi that live in the gut, which has been considered a forgotten organ of the human body

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