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Clinical trials have shown that patients can achieve an average weight loss of 15% to 21% of their starting body weight over a period of 72 weeks (about 1.5 years), with the most significant changes often occurring within the first year

Quick Answer: Tirzepatide does slow digestion by delaying gastric emptying through its GLP-1 receptor agonist activity, causing food to move more slowly from the stomach into the small intestine

Because of their immunosuppressive properties, there are a range of adverse effects seen with these medications.4 JAK inhibitors have been demonstrated to increase the risk of herpes zoster, with a recent systematic review looking at 47 randomized controlled trials showing a 3 times higher odds of shingles in those treated with upadacitinib compared with those without treatment.5 Basic science studies have demonstrated the crucial role of JAK pathways in the proliferation of CD41 lymphocytes for optimal antiviral functions.6 It is possible that downregulation of these pathways by JAK inhibitors could cause varicella-zoster virus reactivation and lead to increased herpes zoster incidence.6 Theoretically, the same could be said about HHV-8 reactivation leading to KS development in patients treated with JAK inhibitors

According to the FDA prescribing information, taking oral semaglutide with food or beverages markedly reduces absorption