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Deletion of Ndufs2 caused a complete loss of CI activity with secondary reduction of CIII in gWAT

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Measurement of the levels of intracellular GSH and the relative expression of NRF2, GPX4 and SOD1 in tissue samples following neoadjuvant chemotherapy To further verify the role of GSH metabolism in chemotherapy resistance, we analyzed breast cancer data from the Gene Expression Omnibus (GEO) dataset (GEO: GSE140494)