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Rashid et al

1 Introduction The glutathione peroxidase family (GPX) is a family of antioxidant enzymes that are an essential class of selenoenzymes in mammals ( 2 O 2 or organic hydroperoxides to water or corresponding alcohols, thereby mitigating their toxicity ( In mammals, GPX works with superoxide dismutase and catalase to form an enzymatic antioxidant system that reduces reactive oxygen species (ROS) and limits their toxicity

The angiogenesis hypothesis may provide new insights by suggesting a decline in angiogenic growth factors with age, which in turn leads to a reduction in microcirculation in the body (Ambrose 2016)

peripheral vascular thrombosis

DTI indicated disorganised WM in the ipsilateral corpus callosum, corroborated by myelin basic protein (MBP) analysis, with increased CD68+/MBP+ colocalisation suggesting microglial/macrophage-mediated myelin phagocytosis