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How does MEK activate AKT

The standard dose is 1000 mcg (1 mg) per month

10.1002/syn.20206 Synapse 166 SargentM.Goenaga-InfanteH.InagakiK.MaL.MeijaJ.PramannA.et al (2019)

At 1 mM extracellular NH 4 Cl it amounted to 30 nmol/mg protein per min, which in vivo (100 g protein/g wet wt.) would equal 3 mol/g wet wt per min, or about one half of the in vivo rate of the glutamineglutamate (GABA) cycle (Table 1)