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Most weight loss specialists now reserve this combination for refractory cases where GLP-1 monotherapy has failed

Although alpha glucosidase inhibitors reduced A1C, they did not reduce weight or total daily insulin dose, and were associated with significant gastrointestinal side effects, being 5 times more likely to be discontinued due to adverse effects than placebo [81]

The following Ozempic alternatives are not specifically approved for prediabetes but are used to improve insulin sensitivity and lower high blood sugar levels

When to Speak to Your GP About Side Effects If you are taking Ozempic and notice changes in your mood, behaviour, or emotional wellbeing, it is important to discuss these with your GP or diabetes specialist nurse

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