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Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)

Methylene blue is not cumulative in the way peptides are the half-life is short so the daily dose is what produces the day-to-day effect

10.1002/gps.1469 Int

Theres no research on the long-term effects of chanca piedra, so it may be wise to limit the time you take the supplement to 12 weeks or less a duration that has been studied in humans ( In the studies that have been done on chanca piedra, there doesnt appear to be any risks to stopping the supplement suddenly

The effects of Spirulina intake on clinical and metabolic parameters in Alzheimer's disease: a randomized, double-blind, controlled trial