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Thus, evidence of increased brain oxidative damage in the development of central nervous system pathologies has been reported for neurodegenerative diseases, including Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis, cerebrovascular disorders, demyelinating diseases, and psychiatric disorders (Sorce and Krause, 2009)

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VPA-exposed rats exhibited significantly prolonged escape latencies compared to controls ( P 0.05 )

[126] Robitaille K, Guertin M, Jamshidi A, et al

Kanda, S