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The main intracellular producer of ROS and RNS is the mitochondrial respiratory chain (Ray et al., 2012) and the increase of oxidative damage or release of mitochondrial DNA observed during mitochondrial dysfunction act as danger-associated signals (DAMPs), which initiate the immune response through pro-inflammatory NF-B activation (Picca et al., 2020)

Apply an appropriate amount onto a loofah or a wash cloth and massage gently onto body until lather forms

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This disease complexity presents a challenge in the treatment of epilepsy, where available anti-seizure medications (ASMs) that are tailored to the epilepsy syndrome generally only achieve a 3050% responder rate (Vezzani et al., 2019)