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Description

The study established the ~6-day half-life, dose-proportional pharmacokinetics, and the 1272 hour Tmax window

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Respuesta en diabetes tipo 2 : En personas con diabetes tipo 2, la respuesta a GLP-1 est relativamente preservada aunque atenuada, mientras que la respuesta a GIP est frecuentemente disminuida, lo que inicialmente llev a los investigadores a enfocarse en agonistas de GLP-1

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The highest dose of orforglipron helped patients lose on average 10.5% of their weight, or 22.9 pounds, on average at 72 weeks, compared to 2.2% weight loss among those who took a placebo

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