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An exploratory DEXA substudy of the STEP 1 trial (140 participants, 68 weeks) found that semaglutide 2.4 mg produced a 19.3% reduction in total fat mass and a 9.7% reduction in total lean body mass with the proportion of lean mass relative to total body mass actually increasing by 3.0 percentage points because fat was lost more rapidly. These results were exploratory and not corrected for statistical multiplicity, so they should be interpreted accordingly

HepG2 cells were obtained from European Collection of Cell Cultures (ECACC, Salisbury, United Kingdom)

The two factors most strongly associated with preserving muscle mass during weight loss are adequate protein intake and resistance training

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Cold medication is a frequent culprit that many patients overlook