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Specification and emulation of the reference trial including our expansion studies are stated in the Supplementary Information, following the TrAnsparent ReportinG of observational studies Emulating a Target trial (TARGET) guideline (Supplementary Tables 2729) 42

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1 That survival is not incidental

Overall, most people taking high-dose elecoglipron reached their blood sugar targets 90% got their A1C under 7% and 85% got it under 6.5%

Many patients do not think this risk was properly disclosed to them by Novo Nordisk in a clear and timely manner