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However, HeLa cells are much more sensitive, with 2.5 nM (per million cells) of doxorubicin resulting in up to 80% GSH depletion for the same exposure time 38

Butyrylated starch is less susceptible to enzymic hydrolysis and increases large-bowel butyrate more than high-amylose maize starch in the rat

Nevertheless, greater use of uricase knock-out animals and similar humanising paradigms may prove valuable in studying the interaction of UA with clinically relevant models of PD neurodegeneration