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No other main effects of significant interactions were present for CXCL1 ( p 0.093)

GLP-1 receptor agonists such as semaglutide are effective for weight loss and metabolic improvement, but some patients report reduced hedonic responses, including diminished pleasure in food and social activities

Furthermore, ischemia-induced mitochondrial calcium overload and permeability transition pore (mPTP) opening exacerbate mitochondrial dysfunction and ROS production (Griffiths and Halestrap, 1993

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