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Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma

Studies in rodents have shown that GLP-1 receptor agonists, including semaglutide, cause dose-dependent and treatment-duration-dependent thyroid C-cell tumors

Antizyme 1 is encoded by the OAZ1 (ornithine decarboxylase antizyme 1) gene

The largest Wegovy trial (STEP program) reported an average ~15% body weight loss, which is markedly higher than results from older drugs like orlistat or appetite suppressants (typically 510%)

By subcutaneous injection (Wegovy): initially 0.25 mg once a week and increased every 4 weeks until the full dose of 2.4 mg is reached