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None of the four is FDA-approved

Real-world evidence is consistent with benefit in routine practice

Beneficial effects are evident across the continuum of human movement, from breaking prolonged sitting with light activity [103] to high-intensity interval training [123]

However, variable expressivity and non-penetrance are common, with many relatives carrying the gene mutation having only mild or absent symptomatology

Given all these unknowns, it may be best for Congress to pump the brakes on expanding GLP-1s in Medicare before we have a better understanding of their full value and a way to pay for it.